What happens if denosumab is stopped abruptly?

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Prepare for the HESI Osteoporosis Case Study Test. Use flashcards and multiple choice questions with detailed explanations. Master the exam!

Multiple Choice

What happens if denosumab is stopped abruptly?

Explanation:
Stopping denosumab abruptly unleashes a rebound in bone turnover. Denosumab blocks RANKL and suppresses osteoclast formation and activity, but its effects fade quickly once the injections stop because there’s no lasting drug stored in bone. As soon as the inhibition wears off, osteoclast activity surges, bone density can decline rapidly, and the risk of vertebral fractures increases, often within the first year or two. To prevent this rebound, another antiresorptive therapy, such as a bisphosphonate, is typically started soon after stopping denosumab.

Stopping denosumab abruptly unleashes a rebound in bone turnover. Denosumab blocks RANKL and suppresses osteoclast formation and activity, but its effects fade quickly once the injections stop because there’s no lasting drug stored in bone. As soon as the inhibition wears off, osteoclast activity surges, bone density can decline rapidly, and the risk of vertebral fractures increases, often within the first year or two. To prevent this rebound, another antiresorptive therapy, such as a bisphosphonate, is typically started soon after stopping denosumab.

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